Formulation, evaluation, and optimization of the omeprazole magnesium multi-unit particulate controlled release tablets using different concentrations of polymers
نویسندگان
چکیده
Multi-Unit Particulates (MUPs) with matrix pellets are used to develop controlled release products of various active pharmaceutical ingredients. They may allow improvement in solubility and thereby bioavailability poorly soluble drugs. Omeprazole magnesium is a derivative benzimidazole which belongs the group proton pump inhibitors that exhibits degradation gastric acid short biological life variability bioavailability. The drug problem was overcome by coating enteric agents disperse gastrointestinal tract more homogenously than single units rapid transit time. Pellets were compressed reduce tampering risk transportation difficulty through esophagus. done bottom spray technique. A batch 5% concentration binder optimized for tablet affects disintegration tablet. cushioning agent employed optimize resistance 12% profile depicted pH 6.8 phosphate buffer followed 0.1N HCl 2 hours. evaluated resistance, similarity factor, SEM, dissolution, stability studies exhibited maximum abrupt duodenal because multi-particulate approach.
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ژورنال
عنوان ژورنال: IP international journal of comprehensive and advanced pharmacology
سال: 2023
ISSN: ['2456-9542', '2581-5555']
DOI: https://doi.org/10.18231/j.ijcaap.2022.040